What is Thymosin Beta 4 (Tβ4)?
- Tβ4 is a naturally-occurring regenerative peptide that exists in the human body. Tβ4 has multiple mechanisms of action, including, promotion of cell migration, cell protection, decrease of apoptosis, promotion of stem cell recruitment and differentiation, collagen maintenance, decreased inflammation, etc. It has shown efficacy in animal models of dermal injury, cardiac ischemia, stroke, spinal cord injury, and traumatic brain injury. It is safe and well tolerated when give topically, systemically, and to the ocular surface. It is thus a bioactive pharmaceutical that can be used to treat various diseases.
- RegeneRx Biopharmaceuticals, Inc. has completed several clinical trials for various diseases using three formulations with Tβ4.
ReGenTree is conducting Phase III clinical trials for patients with dry eye syndrome and with neurotrophic keratopathy in the USA.
In particular, two types of formulations containing Tβ4 have received Orphan Drug Designation from the USA FDA as a treatment for Epidermolysis Bullosa and for Neurotrophic Keratopathy.